Synthesis of Tc-D,D-HMPAO and Tc-L,L-HMPAO and their comparison of chemical and biological properties

Authors
Ding, HJ Huang, YF Tzeng, CC Wei, LM Yeh, SJ
Citation
Hj. Ding et al., Synthesis of Tc-D,D-HMPAO and Tc-L,L-HMPAO and their comparison of chemical and biological properties, BIOORG MED, 9(22), 1999, pp. 3199-3202
Citations number
16
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
22
Year of publication
1999
Pages
3199 - 3202
Database
ISI
SICI code
0960-894X(19991115)9:22<3199:SOTATA>2.0.ZU;2-3
Abstract
Tc-D,D- and Tc-L,L-HMPAO were synthesized. The stability of Tc-D,D- and Tc- L,L-HMPAO in vitro is similar to that of d,l-isomers by the spectrophotomet ric and three strips methods. Cerebral uptake (%D in brain) for the L,L-iso mer is higher than the D,D- and d,1-isomer in rats. Delayed studies shows t hat TC-L,L-HMPAO reveals less washout and reflects a higher cerebral deposi tion properties than the D,D- and d,l-isomer. (C) 1999 Elsevier Science Ltd . All rights reserved.