Synthesis and biological evaluation of two novel DAT-binding technetium complexes containing a piperidine based analogue of cocaine

Authors
Hoepping, A Babich, J Zubieta, JA Johnson, KM Machill, S Kozikowski, AP
Citation
A. Hoepping et al., Synthesis and biological evaluation of two novel DAT-binding technetium complexes containing a piperidine based analogue of cocaine, BIOORG MED, 9(22), 1999, pp. 3211-3216
Citations number
10
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
22
Year of publication
1999
Pages
3211 - 3216
Database
ISI
SICI code
0960-894X(19991115)9:22<3211:SABEOT>2.0.ZU;2-U
Abstract
Two new technetium complexes containing a piperidine template have been syn thesized and evaluated as possible leads for the development of dopamine tr ansporter (DAT) imaging agents. Binding data for the corresponding rhenium complexes containing either a monoaminomonoamide (MAMA') or a diaminodithio l (DADT) chelating unit exhibited significant affinity for the DAT. Initial biodistribution studies in rats revealed only a low brain uptake. (C) 1999 Elsevier Science Ltd. All rights reserved.