Unsymmetrical cyclic ureas as HIV-1 protease inhibitors: Novel biaryl indazoles as P2/P2' substituents

Authors
Patel, M Rodgers, JD McHugh, RJ Johnson, BL Cordova, BC Klabe, RM Bacheler, LT Erickson-Viitanen, S Ko, SS
Citation
M. Patel et al., Unsymmetrical cyclic ureas as HIV-1 protease inhibitors: Novel biaryl indazoles as P2/P2' substituents, BIOORG MED, 9(22), 1999, pp. 3217-3220
Citations number
15
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
22
Year of publication
1999
Pages
3217 - 3220
Database
ISI
SICI code
0960-894X(19991115)9:22<3217:UCUAHP>2.0.ZU;2-S
Abstract
The preparation of unsymmetrical cyclic ureas bearing novel biaryl indazole s as P2/P2' substituents was undertaken, utilizing a Suzuki coupling reacti on as the key step. Compound 6i was equipotent to the lead compound of the series SE063. (C) 1999 DuPont Pharmaceuticals Company. Published by Elsevie r Science Ltd. All rights reserved.