Dicationic 2-fluorenonylcarbapenems: Potent anti-MRS agents with improved solubility and pharmacokinetic properties

Authors
Greenlee, ML Laub, JB Rouen, GP DiNinno, F Hammond, ML Huber, JL Sundelof, JG Hammond, GG
Citation
Ml. Greenlee et al., Dicationic 2-fluorenonylcarbapenems: Potent anti-MRS agents with improved solubility and pharmacokinetic properties, BIOORG MED, 9(22), 1999, pp. 3225-3230
Citations number
18
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
22
Year of publication
1999
Pages
3225 - 3230
Database
ISI
SICI code
0960-894X(19991115)9:22<3225:D2PAAW>2.0.ZU;2-S
Abstract
The synthesis and biological evaluation of a series of dicationic-substitut ed 2-fluorenonylcarbapenems is described. This class of compounds showed en hanced water solubility while maintaining potent activity against MRS. Intr oduction of a beta 1--methyl substituent was found to improve pharmacokinet ics. (C) 1999 Elsevier Science Ltd. All rights reserved.