Malignant fibrous histiocytoma after allogeneic bone marrow transplantation

A 24-year-old woman with CML underwent allogeneic BMT in August 1995 from a one-antigen HLA mismatched brother. Conditioning included BuCy2 and CsA an d MTX were used to prevent GVHD. In July 1997 she developed right leg pain, lytic bone lesions of distal femur and a solid mass of soft tissue. Histol ogical diagnosis of malignant fibrous histiocytoma was made. Despite treatm ent with surgery and chemotherapy (doxorubicin and ifosfamide), the patient died 1 year later with local recurrence of the tumor and liver, lung and b rain metastases. The CML was in CR.