Event-related potentials were recorded during a delayed matching-to-sample
design from 17 volunteers (5 f) using high-resolution (65 channels) EEG-rec
ordings. In the two-stimulus paradigm, the 500-ms stimulus S1 comprised a v
isual pattern of two diamonds differing in size, angular rotation and locat
ion; in the delay period, Working Memory (WM) load was varied in the follow
ing way: a stimulus-free interval of 1 s was followed by a 6-s presentation
either of a pattern identical to the S1 (low WM load) or of a pattern diff
ering from S1 thigh WM load). The 500-ms stimulus S2 comprised one diamond;
the subject's task was to indicate by left- or right-hand (respectively) b
utton press, whether the S2 matched the (a) left- or (b) right-positioned S
1-diamond, or (c) did not match at all(NoGo). The topographical distributio
n of activity in the time intervals (a) following S1-offset, (b) during the
WM manipulation interval and (c) prior to S2 were evaluated in the signal
(scalp potential) and source (Minimum Norm) space. Following S1-offset the
ERP pattern was characterised by negativity over posterior areas, slightly
more so over the right hemisphere. In the subsequent 6-s interval high WM l
oad elicited a larger negative slow ERP than low WM load, the negativity in
crease due to high WM load being larger over frontal than central areas. So
urce modelling indicated activity in anterior areas under high, and posteri
or activity under low WM load. Asymmetry of activity, although indicating a
shift to left-hemispheric activity under high compared to low WM load, var
ied considerably between subjects. Results suggest that high-resolution ERP
recordings allow to examine cortical activity during WM challenge.