In many continuous fermentation processes, the control objective is to maxi
mize productivity per unit time. The optimum operational point in the stead
y state can be obtained by maximizing the productivity rate using feed subs
trate concentration as the independent variable with the equations of the s
tatic model as constraints. In the present study, three model-based control
schemes have been developed and implemented for a continuous fermenter. Th
e first method modifies the well-known dynamic matrix control (DMC) algorit
hm by making it adaptive. The other two use nonlinear model predictive cont
rol algorithms (NMPC, nonlinear model predictive control) for calculation o
f control actions. The NMPC1 algorithm, which uses orthogonal collocation i
n finite elements, acted similar to NMPC2, which uses equidistant collocati
on. These algorithms are compared with DMC. The results obtained show the g
ood performance of nonlinear algorithms.