Hepatitis B and C virus infection in Romanian non-Hodgkin's lymphoma patients

We determined the hepatitis C virus (HCV) antibodies (anti-HCV) and the hep atitis B virus (HBV) surface antigen (HBsAg) in a cohort of 68 consecutive non-Hodgkin's lymphoma (NHL) patients diagnosed and treated in our institut ion between December 1997 and March 1999. 27 cases were diagnosed as lo low -grade, 33 as intermediate-grade, and eight as high-grade NHL, In 35 cases (51.4%) we found evidence of either HCV or HBV infection. Anti-HCV antibodi es were found in 20 patients (29.5%) and HBsAg was found in 21 patients (30 .8%), In six patients both anti-HCV and HBsAg were present. Anti-HCV were p resent in 12/27 low-grade NHL cases (44.4%) and in 8/41 intermediate/high-g rade (aggressive) NHL cases (19.5%, P < 0.03). HBsAg was found in 10/27 low -grade NHL cases (37%) and in 11/41 aggressive NHL cases (26.8%). Evidence of liver disease, as reflected by elevated aminotransferases or typical alt erations at liver biopsy, was present in eight patients. Cryoglobulins were present in six patients, all anti-HCV positive and with low-grade NHL. The prevalence of both HCV antibodies and HBsAg was significantly higher (P < 0.0001) in our NHL cases than in a sample of the general Romanian populatio n where the prevalence of anti-HCV was 4.9% and that of HBsAg was 6.3%. It is difficult to say whether either HCV or HBV had actually been involved in lymphomagenesis or if alpha-interferon treatment would be effective in thi s subset of patients.