In vivo glucose sensing for diabetes management: progress towards non-invasive monitoring

A device for continuous in vivo monitoring of glutose concentration in peop le with diabetes has been a clinical and research priority for many years b ut now has an urgency which is probably unquestioned in diabetes tare. The purpose of this article is to explain recent advances in technology that ar e bringing glutose sensors closer to routine use and to highlight some of t he remaining problems. Important new technologies include artificial recept ors for glutose, tissue fluid sampling techniques, and new approaches to no n-invasive sensing, such as fluorescence lifetime measurements.