Potential interactions of zinc in the neuroendocrine-endocrine disturbances of diabetes mellitus type 2

An accumulation of evidence implicates leptin, insulin, glucocorticoids, pr oopiomelanocortin (POMC), and neuropeptide Y (NPY) interactions as being in tegral to metabolic control associated with neuroendocrine-endocrine functi oning. Dysfunction of neuroendocrine-endocrine interactions contributes to the metabolic disturbances of diabetes mellitus type 2 (DM-2). Since Zn has a direct impact on the healthy functioning of hormonal and neuropeptide ba lance, it is possible that altered Zn status and metabolism in DM-2 are inv olved in some of the metabolic dysfunctions of DM-2.