The pore-size distribution (PSD) of a liquid-saturated porous medium can be
determined by inverse size-exclusion chromatography (ISEC) under suitable
conditions. To quantify the limitations of longitudinal dispersion, intrapa
rticle diffusion, and adsorption, we present a mathematical model for chrom
atographic procedures with polydisperse solutes. Results are applicable to
either inverse or ordinary SEC. The conventional ISEC procedure with monodi
sperse polymer standards is a special case of the general development. Chro
matographic responses for polydisperse solutes permit determination of the
pore-size distribution by a deconvolution procedure if adsorption is neglig
ible. (C) 1999 Elsevier Science Ltd. All rights reserved.