Synthesis of new fluidity-enhanced amphiphilic compounds for soluble protein two-dimensional crystallization purpose

The synthesis of new amphiphilic compounds is described. The structures are rationally designed for soluble protein two-dimensional (2D) crystallizati on purpose. Special attention is devoted to fluidity properties expected of resulting monolayers. A series of 13 compounds was prepared containing uns aturated, branched or fluorinated alkyl chains. Structures are either symme trical or dissymmetrical and present a hydroxyl group as polar head, eventu ally complemented with two other 'secondary' hydrophilic functions. (C) 199 9 Elsevier Science Ireland Ltd. All rights reserved.