E. Fransen et al., Impact of blood transfusions on inflammatory mediator release in patients undergoing cardiac surgery, CHEST, 116(5), 1999, pp. 1233-1239
Citations number
24
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Study objectives: This study was conducted to investigate whether intraoper
ative blood transfusions affect the release of proinflammatory mediators in
patients undergoing cardiac surgery. Therefore, we measured plasma levels
of bactericidal permeability increasing protein (BPI) as a marker of neutro
phil activation, interleukin-6 (IL-6), lipopolysaccharide binding protein (
LBP), and C-reactive protein (CRP). In addition, these mediators, except CR
P, were also measured in packed red cell units (PCs) administered to these
patients.
Design: Prospective study.
Setting: Cardiopulmonary surgery department in a university hospital.
Patients: One hundred fourteen consecutive patients undergoing cardiac surg
ery. Interventions: Blood samples were taken at induction of anesthesia, at
the start of aortic cross-clamping, at aortic unclamping, and at 0.5, 4, 8
, and 18 h thereafter.
Results: Thirty-six patients received PC intraoperatively. BPI levels in pa
tients who received transfusions were significantly higher at 0.5 and 4 h a
fter aortic unclamping than in patients without transfusions (p < 0.05), an
d increased with the number of PC administered. IL-6 levels at 0.5, 4, and
18 h after aortic unclamping were also significantly higher in patients who
received transfusions (p < 0.01). BPI was found in all units of packed red
cells tested at concentrations up to 15 times preoperative plasma levels i
n patients. However, PC IL-6 could be detected in none of the samples. Plas
ma levels of LBP and CRP were similar in both patient groups. LBP was found
in very low concentrations in all PC. Patients who received intraoperative
transfusions had a worse postoperative performance.
Conclusions: Intraoperative PC transfusions do contribute to the inflammato
ry response after cardiac surgery both by enhancing part of the response an
d by directly changing plasma concentrations of inflammatory mediators. Fur
thermore, these data show that intraoperative PC transfusion is associated
with a worse postoperative performance.