Context: Acute lung injury (ALI) and ARDS are currently defined by the Amer
ican-European Consensus Conference (IIE-CC) definition criteria, which cont
ain a radiographic criterion. The accuracy or reliability of this consensus
radiographic definition has not been evaluated, and no radiographic defini
tion of ALI-ARDS has been evaluated by a large international group of exper
ts.
Objective: To study the interobserver variability in applying the AECC radi
ographic criterion for ALI-IIRDS.
Design: Survey.
Participants: A convenience sample of 21 experts selected from participants
attending the 1997 Toronto Mechanical Ventilation Workshop and from member
s of the National Institutes of Health ARDS Network.
Outcome measures: Participants reviewed 28 randomly selected chest radiogra
ph from critically ill, hypoxemic (Pao(2)/fraction of inspired oxygen ratio
, < 300) patients and decided whether the radiograph fulfilled the AECC def
inition for ALI-IIRDS.
Results: Interobserver agreement in applying the AECC definition for ALI-AR
DS was moderate (kappa = 0.55; 95% confidence interval, 0.52 to 0.57), Thir
teen radiographs (43%) showed nearly complete agreement (defined as 20 or 2
1 readers in agreement). Nine radiographs (32%) had more than or equal to f
ive dissenting readers. The percentage of radiographs interpreted as consis
tent with Al;I-ARDS by individual readers ranged from 36 to 71%. Participan
ts commented that mild infiltrates, pleural effusions, atelectasis, isolate
d lower lobe involvement, radiographic technique, and overlying monitoring
equipment posed the most difficulties.
Conclusions: The radiographic criterion used in the current AECC definition
for ALI-ARDS showed high interobserver variability when applied by expert
investigators in the fields of mechanical ventilation and ARDS. This variab
ility may result in differences in ALI-ARDS populations at different clinic
al research centers and may make it difficult for clinicians to apply the r
esults of clinical trials to their patients. Modifications to the radiograp
hic criterion or annotated reference radiograph may improve the reliability
of future definitions for ALI-ARDS.