Natural killer cells: Stress out, turn on, tune in

Authors
Diefenbach, A Raulet, DH
Citation
A. Diefenbach et Dh. Raulet, Natural killer cells: Stress out, turn on, tune in, CURR BIOL, 9(22), 1999, pp. R851-R853
Citations number
14
Categorie Soggetti
Experimental Biology
Journal title
CURRENT BIOLOGY
ISSN journal
09609822 → ACNP
Volume
9
Issue
22
Year of publication
1999
Pages
R851 - R853
Database
ISI
SICI code
0960-9822(19991118)9:22<R851:NKCSOT>2.0.ZU;2-3
Abstract
Natural killer cells attack tumor cells, infected cells and some normal cel ls, but the basis of their specificity is not completely understood. Recent studies indicate that epithelial tumor cells upregulate a stress-induced M HC class-I-like protein termed MICA, triggering NK cells via a recently des cribed receptor called NKG2D.