Homozygous factor-V mutation as a genetic cause of perinatal thrombosis and cerebral palsy

A 5-year old girl with cerebral palsy (GP), preterm birth, postnatal aortic thrombus, and cerebellar venous infarction who is homozygous for the throm bophilic factor-V Leiden (fVL) mutation is reported. The role of hereditary thrombophilic disorders in the development of perinatal vascular lesions s uch as aortic thrombi, renal-vein thrombosis, venous-sinus thrombosis, and cerebral infarction is unknown. This case report brings into question a pot ential association between fVL, perinatal vascular lesions, perinatal strok e, and CP.