REACTIVITY OF CARBOCYCLIC 4-MEMBERED RADICALS FOR THE PREPARATION OF CARBOCYCLIC ANALOGS OF OXETANOCINS

Authors
ISHIGAMI S TOGO H YOKOYAMA M
Citation
S. Ishigami et al., REACTIVITY OF CARBOCYCLIC 4-MEMBERED RADICALS FOR THE PREPARATION OF CARBOCYCLIC ANALOGS OF OXETANOCINS, Journal of the Chemical Society. Perkin transactions. I, (17), 1994, pp. 2407-2412
Citations number
47
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
17
Year of publication
1994
Pages
2407 - 2412
Database
ISI
SICI code
0300-922X(1994):17<2407:ROC4RF>2.0.ZU;2-#
Abstract
New carbocyclic four-membered C-nucleosides have been synthesized from the corresponding carboxylic acids and heteroaromatic compounds by th e use of the Barton radical reaction. These carbocyclic nucleosides ar e analogues of oxetanosyl and cyclobutyl N-nucleosides which exhibit p otent antiviral activities. The present synthetic routes provide a met hod for the preparation of cyclobutyl C-nucleosides.