Combining nefazodone and midazolam during ECT

We report the case of a patient suffering from dysthymia. He underwent succ essful ECT treatment and was medicated with nefazodone and midazolam. Compa ring the EEG and motor seizure duration in the periods with and without mid azolam, no significant differences were recorded, but the dosage of thiopen tal and of succinylcholine had to be increased markedly after midazolam was discontinued (P < 0.05; ANOVA). This case indicates a substantial pharmaco dynamic interaction between nefazodone, midazolam, thiopental, and succinyl choline. (C) 1999 Editions scientifiques et medicales Elsevier SAS.