Morphological, thermoanalytical and crystallographic study of different sulphadimidine crystals

The sulphonamide antibacterials including Sulphadimidine as a short-acting drug is well absorbed from the gastrointestinal tract, and 80 to 90% of it is bound to the plasma protein. The commercial products exhibit various mor phologies that influence the preparation of the solid dosage forms. The pow der mixture must have adequate flowability and compactibility during direct compression and capsule filling. These properties are influenced by the mo rphological parameters of the particles, and are additionally important in the preparation of granules as concerns the distribution of the drug partic les. The aim of the present work was to compare the morphological, thermoan alytical and structural properties of sulphadimidine samples obtained from three different batches.