The role of RXR-alpha in retinoic acid-induced cleft palate as assessed with the RXR-alpha knockout mouse

Authors
Nugent, P Sucov, HM Pisano, MM Greene, RM
Citation
P. Nugent et al., The role of RXR-alpha in retinoic acid-induced cleft palate as assessed with the RXR-alpha knockout mouse, INT J DEV B, 43(6), 1999, pp. 567-570
Citations number
32
Categorie Soggetti
Cell & Developmental Biology
Journal title
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
ISSN journal
02146282 → ACNP
Volume
43
Issue
6
Year of publication
1999
Pages
567 - 570
Database
ISI
SICI code
0214-6282(199909)43:6<567:TRORIR>2.0.ZU;2-P
Abstract
Treatment of pregnant mice with retinoic acid (RA) in mid-gestation produce s cleft palate and limb defects in the fetuses. RXR-alpha has been previous ly shown to mediate the teratogenic effects of RA in the limb. In this stud y, we show that RXR-alpha is also involved in retinoid-induced palatal clef ting. Treatment of RXR-alpha knockout mice with a teratogenic dose of RA on gestation day 11 or 12 induces cleft palate at a lower frequency than that seen in wild-type animals.