Pre-clinical evaluation of a two-channel microwave hyperthermia system with adaptive phase control in a large animal

A pre-clinical assessment of the heating capabilities of a two-channel 915 MHz Microfocus-1000 hyperthermia system, with adaptive phase control, was c arried out in a series of experiments using a large animal model. The resul ts of the experimental measurements of specific absorption rate (SAR) and t issue temperature show that when muscle tissue of the hind legs of pigs was compressed to 6.5-7 cm, then a pair of parallel opposed, coherently driven , transverse electromagnetic wave applicators could elevate the temperature in deep tissue to therapeutic levels without overheating superficial tissu es when the phase difference between applicators was determined by the adap tive phase control algorithm.