Regulation of mitotic activity in the rat cornea upon protective and therapeutic action of p-aminobenzoic acid in experiments with X-irradiation

The protective and therapeutic action of p-aminobenzoic acid (PABA), at dos es effective in interferon induction (Akberova et al., 1999), was studied o n the rat cornea in the experiments with X-irradiation (5 Gy). PABA at 10 m g/kg preserved the postradiation mitotic activity at the level of irradiate d control, while at 1.4 and 100 mg/kg it increased the mitotic activity abo ve the control level. In all experiments, PABA at all three doses decreased the rate of pathological mitoses in equal proportions to the total number of mitoses.