Regulation of mitotic activity in the rat cornea upon protective and therapeutic action of p-aminobenzoic acid in experiments with X-irradiation

Citation
Og. Stroeva et Ig. Panova, Regulation of mitotic activity in the rat cornea upon protective and therapeutic action of p-aminobenzoic acid in experiments with X-irradiation, IAN BIOL, (5), 1999, pp. 613-616
Citations number
8
Categorie Soggetti
Biology
Journal title
IZVESTIYA AKADEMII NAUK SERIYA BIOLOGICHESKAYA
ISSN journal
00023329 → ACNP
Issue
5
Year of publication
1999
Pages
613 - 616
Database
ISI
SICI code
0002-3329(199909/10):5<613:ROMAIT>2.0.ZU;2-R
Abstract
The protective and therapeutic action of p-aminobenzoic acid (PABA), at dos es effective in interferon induction (Akberova et al., 1999), was studied o n the rat cornea in the experiments with X-irradiation (5 Gy). PABA at 10 m g/kg preserved the postradiation mitotic activity at the level of irradiate d control, while at 1.4 and 100 mg/kg it increased the mitotic activity abo ve the control level. In all experiments, PABA at all three doses decreased the rate of pathological mitoses in equal proportions to the total number of mitoses.