Influence of polyethylene terephthalate on the release of growth factors by human endothelial cells

Authors
Cenni, E Verri, E Granchi, D Gamberini, S Corradini, A Di Leo, A Montanaro, L Pizzoferrato, A
Citation
E. Cenni et al., Influence of polyethylene terephthalate on the release of growth factors by human endothelial cells, J BIOM SC P, 10(9), 1999, pp. 891-900
Citations number
39
Categorie Soggetti
Multidisciplinary
Journal title
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
ISSN journal
09205063 → ACNP
Volume
10
Issue
9
Year of publication
1999
Pages
891 - 900
Database
ISI
SICI code
0920-5063(1999)10:9<891:IOPTOT>2.0.ZU;2-J
Abstract
The influence of polyethylene terephthalate (PET) on the release of platele t derived growth factor AB (PDGF-AB) and basic fibroblast growth factor (bF GF) by in vitro cultured human endothelial cells was assessed by enzyme imm unoassay. No significant differences were observed in the production of PDG F-AB with respect to the negative control cultures. A significant increase was observed in the production of bFGF after 48 and 72 h with respect to th e negative control cultures. It can be concluded that PET may induce an inc rease in the production of basic FGF in endothelial cells.