The nutritional preferences of twelve strains of genus Streptosporangium we
re studied as a first step in the design of production media to be used in
a natural products screening program. The media ingredients included 20 alp
ha-amino acids, 35 carbon sources (monosaccharides, oligosaccharides, polys
accharides, polyalcohols and others), 22 complex sources (meals, peptones,
yeast derivatives, etc.). The growth of these strains in the presence of th
ese culture media ingredients and the production of inhibitory substances a
gainst Bacillus subtilis were analyzed in solid-phase cultures. The results
show that the isolates studied did not exhibit a common trend in their pre
ference of nutrient sources, either for to support their growth or the prod
uction of anti-B. subtilis substances.