A convenient one-pot synthesis of pyrimido[4,5-b]quinolines as 5-deaza non-classical antifolate inhibitors

Authors
Naby, HAA Mekheimer, RA Abd-Elhameed, AM Sadek, KU
Citation
Haa. Naby et al., A convenient one-pot synthesis of pyrimido[4,5-b]quinolines as 5-deaza non-classical antifolate inhibitors, J CHEM R-S, (11), 1999, pp. 678-679
Citations number
14
Categorie Soggetti
Chemistry
Journal title
JOURNAL OF CHEMICAL RESEARCH-S
ISSN journal
03082342 → ACNP
Issue
11
Year of publication
1999
Pages
678 - 679
Database
ISI
SICI code
0308-2342(199911):11<678:ACOSOP>2.0.ZU;2-M
Abstract
A convenient one-pot synthesis of pyrimido[4,5-b] quinolines as non-classic al 5-deaza antifolate inhibitors by the reaction of 6-amino-4-oxo-2-thioxot etrahydropyrimidine 1 with aromatic aldehydes and dimedone is reported.