Lipid-lowering medication and risk of injury

Meta-analyses of early primary prevention trials of lipid-lowering therapie s suggested increased risk of injury deaths among treated persons. Our popu lation-based case-control study examined the association of lipid-lowering medication use with fatal and nonfatal injuries in 298 cases and 332 contro ls. No increased injury risk was observed among current (OR = 0.46, 95% CI 0.18-1.21) or past users (OR = .92, 95% CI 0.44-1.95), after adjustment for behavioral disorders, medical conditions, and health status. Stratified an alyses did not reveal sub-groups at significantly increased risk. These res ults, consistent with recent clinical trials and meta-analyses, suggest no increased injury risk associated with lipid-lowering medications. (C) Elsev ier Science, Inc.