Anti-diarrhoeal evaluation of Clerodendrum phlomidis Linn. leaf extract inrats

Authors
Rani, S Ahamed, N Rajaram, S Saluja, R Thenmozhi, S Murugesan, T
Citation
S. Rani et al., Anti-diarrhoeal evaluation of Clerodendrum phlomidis Linn. leaf extract inrats, J ETHNOPHAR, 68(1-3), 1999, pp. 315-319
Citations number
8
Categorie Soggetti
Pharmacology & Toxicology
Journal title
JOURNAL OF ETHNOPHARMACOLOGY
ISSN journal
03788741 → ACNP
Volume
68
Issue
1-3
Year of publication
1999
Pages
315 - 319
Database
ISI
SICI code
0378-8741(199912)68:1-3<315:AEOCPL>2.0.ZU;2-5
Abstract
A study was undertaken to evaluate the effect of methanolic extract of leav es of Clerodendrum phlomidis Linn. (MECP) (Family: Verbenaceae) for its ant i-diarrhoeal potential against several experimental models of diarrhoea in Wistar albino rats. MECP showed significant inhibitory activity against cas tor oil induced diarrhoea and PGE(2) induced enteropooling in rats. The ext ract also showed a significant reduction in gastrointestinal motility in ch arcoal meal test in rats. The results obtained establish the efficacy and s ubstantiated the folklore claim as an anti-diarrhoeal agent. (C) 1999 Elsev ier Science Ireland Ltd. All rights reserved.