Antinociceptive and anti-inflammatory activity of carumbelloside-I isolated from Caralluma umbellata

The phytochemical study using Caralluma umbellata (Asclepiadaceae) whole pl ant allowed the isolation of a novel pregnane glycoside named carumbellosid e-I (3-0-beta-D-glucopyranosyl-(1 --> 6)-beta-D-glucopyranosyl-3 beta,14 be ta-dihydroxypregn-5-en-20-one). Carumbelloside-I was evaluated for both ant inociceptive activity and anti-inflammatory activity. The antinociceptive a ctivity was evaluated in mice using the writhing test method, while the ant i-inflammatory activity was evaluated in rats using the paw edema test with carrageenin. Carumbelloside-I has significant antinociceptive action. It h as no anti-inflammatory activity. (C) 1999 Elsevier Science Ireland Ltd. Al l rights reserved.