Stability of mefenamic acid in the inclusion complex with beta-cyclodextrin in the solid phase

Authors
Hladon, T Pawlaczyk, J Szfran, B
Citation
T. Hladon et al., Stability of mefenamic acid in the inclusion complex with beta-cyclodextrin in the solid phase, J INCL P MA, 35(3), 1999, pp. 497-506
Citations number
11
Categorie Soggetti
Chemistry
Journal title
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
ISSN journal
13883127 → ACNP
Volume
35
Issue
3
Year of publication
1999
Pages
497 - 506
Database
ISI
SICI code
1388-3127(199911)35:3<497:SOMAIT>2.0.ZU;2-W
Abstract
The inclusion complex of mefenamic acid with beta-cyclodextrin was obtained by the method of coprecipitation from diethyl ether. The product was ident ified by the thermogravimetric and X-ray methods. The complex stability con stants were determined by the potentiometric method. The effect of beta-CD on the solubility and stability of mefenamic acid was analysed.