A novel method to obtain a beta-cyclodextrin inclusion compound by solid state reaction: The ketoprofen case revisited

The ketoprofen/beta-cyclodextrin (beta-CD) inclusion compounds may be conve niently obtained through a solid state reaction at room temperature in the presence of saturated water vapour. Relative to the corresponding complexes produced with the usual coprecipitation method, the new compounds have a h igher ketoprofen content and/or different properties. In particular, the fo rmation reaction is not accompanied by a loss of hydration water, which is released in distinct stages upon heating. The thermodynamics of the dehydra tion process is discussed.