Differential gene expression after implantation of biomaterials into rat gastrointestine

Authors
Lobler, M Sass, M Michel, P Hopt, UT Kunze, C Schmitz, KP
Citation
M. Lobler et al., Differential gene expression after implantation of biomaterials into rat gastrointestine, J MAT S-M M, 10(12), 1999, pp. 797-799
Citations number
8
Categorie Soggetti
Multidisciplinary
Journal title
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
ISSN journal
09574530 → ACNP
Volume
10
Issue
12
Year of publication
1999
Pages
797 - 799
Database
ISI
SICI code
0957-4530(199912)10:12<797:DGEAIO>2.0.ZU;2-D
Abstract
Two biodegradable materials, polyglycolide-copoly(L)-lactide/poly-dioxanone composite and poly(3-hydroxybutyrate), have been employed for surgery in t he gastrointestine of laboratory rats. The tissue response was analyzed at distinct time intervals up to 2 months by differential mRNA display. Two sp ecific PCR fragments were transiently present 7 and 14 days after contact w ith poly(3-hydroxybutyrate). Both fragments represent distinct rat lipases which might play a role in poly(3-hydroxybutyrate) degradation. (C) 1999 Kl uwer Academic Publishers.