Lymphocytic responses and the gradual hippocampal neuron loss following infection with lymphocytic choriomeningitis virus (LCMV)

Citation
Bd. Pearce et al., Lymphocytic responses and the gradual hippocampal neuron loss following infection with lymphocytic choriomeningitis virus (LCMV), J NEUROIMM, 101(2), 1999, pp. 137-147
Citations number
35
Categorie Soggetti
Neurosciences & Behavoir
Journal title
JOURNAL OF NEUROIMMUNOLOGY
ISSN journal
01655728 → ACNP
Volume
101
Issue
2
Year of publication
1999
Pages
137 - 147
Database
ISI
SICI code
0165-5728(19991115)101:2<137:LRATGH>2.0.ZU;2-E
Abstract
Infection of rats with LCMV is known to cause a bi-phasic neurodegeneration characterized by acute T lymphocyte-mediated cerebellar damage, followed b y gradual hippocampal neuron loss that occurs by an undefined mechanism. We found infiltration of CD8 + T-cells (but not CD4 + or NK cells) in the hip pocampus which correlated with the acute phase, but not the chronic hippoca mpal degenerative phase. While immunosuppression of T lymphocytes protected the cerebellum and revealed the infection of corticohippocampal glia, the degeneration in the hippocampus was unabated. These data suggest that T lym phocytes control glial infection and mediate degeneration in the cerebellum but not the hippocampus. (C) 1999 Elsevier Science B.V. All rights reserve d.