Dendrimers with alternating amine and ether generations

Dendrimers having alternating aryl benzyl ether and tertiary amine generati ons and up to 16 bis-(2-methoxyethyl)amine end groups and four internal ter tiary amines were synthesized by sequential etherification, amidation of se condary amines, and LiAlH4 reduction to tertiary amines. The bis-(2-methoxy ethyl)amine dendrimers are soluble in common organic solvents and in aqueou s buffer solutions at pH < 4.7. At 2.8 mM, the dendrimer increases the solu bility of pyrene in water 30-fold, and the solvated pyrene is not aggregate d.