THE SYNTHESIS OF A NEW ACTIVE-SITE ANALOG OF CYTOCHROME-P450 CARRYINGSUBSTRATE RECOGNITION SITES AND ATHIOLATE LIGAND

Authors
AISSAOUI H GHIRLANDA S GMUR C WOGGON WD
Citation
H. Aissaoui et al., THE SYNTHESIS OF A NEW ACTIVE-SITE ANALOG OF CYTOCHROME-P450 CARRYINGSUBSTRATE RECOGNITION SITES AND ATHIOLATE LIGAND, Journal of molecular catalysis. A, Chemical, 113(1-2), 1996, pp. 393-402
Citations number
16
Categorie Soggetti
Chemistry Physical
Journal title
Journal of molecular catalysis. A, Chemical → ACNP
ISSN journal
13811169
Volume
113
Issue
1-2
Year of publication
1996
Pages
393 - 402
Database
ISI
SICI code
1381-1169(1996)113:1-2<393:TSOANA>2.0.ZU;2-R
Abstract
The synthesis of a new mono-bridged iron(III)porphyrin 2 is described which contains all structural elements significant to an active-site a nalogue of cytochrome P450: (i) a thiolate ligand coordinating to the iron, and (ii) a substrate-recognition site provided by two substructu res derived from Kemp's acid which are positioned perpendicular to the porphyrin plane. H-1-NMR experiments show that esters like dimethyl g lutarate bind with K = 137 M(-1).