STATISTICS OF SINGLE-MOLECULE DETECTION

Authors
ENDERLEIN J ROBBINS DL AMBROSE WP GOODWIN PM KELLER RA
Citation
J. Enderlein et al., STATISTICS OF SINGLE-MOLECULE DETECTION, JOURNAL OF PHYSICAL CHEMISTRY B, 101(18), 1997, pp. 3626-3632
Citations number
47
Categorie Soggetti
Chemistry Physical
Journal title
JOURNAL OF PHYSICAL CHEMISTRY B
ISSN journal
15206106 → ACNP
Volume
101
Issue
18
Year of publication
1997
Pages
3626 - 3632
Database
ISI
SICI code
1089-5647(1997)101:18<3626:SOSD>2.0.ZU;2-A
Abstract
A new mathematical approach for the calculation of the photon detectio n statistics in single-molecule detection experiments is presented. Th e approach is based on a path integral representation of the involved probability distributions. A numerical Monte Carlo sampling method for computing the involved path integrals is given. The general ideas are applied to the modeling of measured burst size distributions in singl e-molecule detection experiments with B-phycoerythrin.