ACETOGENIC ISOQUINOLINE ALKALOIDS .80. DETERMINATION OF CONFIGURATIONAT THE BIARYL AXES OF NAPHTHYLISOQUINOLINE ALKALOIDS BY LONG-RANGE NOE EFFECTS

Authors
BRINGMANN G KOPPLER D SCHEUTZOW D PORZEL A
Citation
G. Bringmann et al., ACETOGENIC ISOQUINOLINE ALKALOIDS .80. DETERMINATION OF CONFIGURATIONAT THE BIARYL AXES OF NAPHTHYLISOQUINOLINE ALKALOIDS BY LONG-RANGE NOE EFFECTS, Magnetic resonance in chemistry, 35(5), 1997, pp. 297-301
Citations number
29
Categorie Soggetti
Spectroscopy,Chemistry
Journal title
Magnetic resonance in chemistry → ACNP
ISSN journal
07491581
Volume
35
Issue
5
Year of publication
1997
Pages
297 - 301
Database
ISI
SICI code
0749-1581(1997)35:5<297:AIA.DO>2.0.ZU;2-7
Abstract
One- and two-dimensional NOE and ROE experiments were applied to inves tigate the relative configuration at the stereogenic biaryl axes of na phthylisoquinoline alkaloids, natural biaryl compounds mainly occurrin g as stable atropisomers. The influence of ortho substitution at the b iaryl axes on the dynamic behavior of the atropodiastereomers and the determined NOE effects was investigated. As an example, the axial conf iguration of ancistrobrevine A was elucidated by the method. (C) 1997 by John Wiley & Sons, Ltd.