A DP1 PSEUDOGENE DERIVED FROM AN ABERRANTLY PROCESSED RNA

A fragment of mouse genomic DNA containing a pseudogene corresponding to the processed transcript of the DP1 locus was isolated and analysed . The pseudogene sequence, on comparison with the genomic locus and th e corresponding mRNA indicated the presence of several small deletions and point mutations. In addition, the pseudogene showed a deletion fo r the second exon of the DP1 gene indicating the occurrence of an exon slippage event during its formation. We also describe the chromosomal mapping of the pseudogene to chromosome 1 by fluorescence in situ hyb ridisation and distinguish it from the localisation of the actual muri ne DP1 genomic locus on mouse chromosome 8. (C) 1997 Elsevier Science B.V.