Influence of platelet activating factor on gastrointestinal electrical activity and some haematological and clinical parameters in the conscious miniature pig
E. Wechsung et A. Houvenaghel, Influence of platelet activating factor on gastrointestinal electrical activity and some haematological and clinical parameters in the conscious miniature pig, J VET PHARM, 22(5), 1999, pp. 327-332
Citations number
40
Categorie Soggetti
Veterinary Medicine/Animal Health
Journal title
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
The effects of intravenous (i.v.) infusion of platelet-activating factor (P
AF), 100 ng/kg/min for 10 min, with and without pretreatment with a selecti
ve PAF-antagonist on gastrointestinal electrical activity, arterial pressur
e and clinical and haematological parameters were studied. Conscious miniat
ure pigs with electrodes implanted in the wall of the antrum pylori and sma
ll and large intestine were used. Platelet-activating factor induced restle
ssness or depression, shivering, tachypnoea and coughing, retching and vomi
ting, hypotension and a delayed and sustained increase in leucocyte count w
ith an increase in percentage of segmented neutrophils. The PAF-antagonist,
SAH 63-675, administered at 10 mg/kg intravenously, inhibited these effect
s, Platelet-activating factor resulted in a decrease in electrical activity
in the antrum and large intestine, whereas small intestinal activity was n
ot significantly influenced, Pretreatment with the antagonist suppressed th
ese inhibitory effects.