METAL-MODIFIED NUCLEOBASE PAIRS INVOLVING 7,9-DIMETHYLGUANINE - TRANS-A(2)PT(II) ANALOGS (A=NH3 OR CH3NH2) OF WATSON-CRICK GC AND HOMO GG PAIRS

Authors
METZGER S ERXLEBEN A LIPPERT B
Citation
S. Metzger et al., METAL-MODIFIED NUCLEOBASE PAIRS INVOLVING 7,9-DIMETHYLGUANINE - TRANS-A(2)PT(II) ANALOGS (A=NH3 OR CH3NH2) OF WATSON-CRICK GC AND HOMO GG PAIRS, JBIC. Journal of biological inorganic chemistry, 2(2), 1997, pp. 256-264
Citations number
29
Categorie Soggetti
Biology,"Chemistry Inorganic & Nuclear
Journal title
JBIC. Journal of biological inorganic chemistry → ACNP
ISSN journal
09498257
Volume
2
Issue
2
Year of publication
1997
Pages
256 - 264
Database
ISI
SICI code
0949-8257(1997)2:2<256:MNPI7->2.0.ZU;2-9
Abstract
The analogy between H-bonded nucleobase pairs and their metalated anal ogues is extended to the hemiprotonated pair of 7,9-dimethylguanine (7 ,9-DimeG) and the Watson-Crick and reversed Watson-Crick pair between 7,9-dimethylguaninium (7,9-DimeGH(+)) and 1-methylcytosine (1-MeC). Th e crystal structure analyses of two model compounds, trans-[Pt(CH3NH2) (2)(7,9-DimeG-N1)(2)] (NO3)(2) (1) and trans-[Pt(NH3)(2)(1-MeC-N3)(7,9 -DimeG-N1)](PF6)(2) . 2.5 H2O (3a) are reported. Pt binding is through N1 of 7,9-DimeG and N3 of 1-MeC. In solution, 3a exists in a mixture with Watson-Crick and reversed Watson-Crick arrangements of the two ba ses, depending on solvent, concentration and anions.