Accumulated basement membrane material in hyalinizing trabecular tumors ofthe thyroid

Citation
R. Katoh et al., Accumulated basement membrane material in hyalinizing trabecular tumors ofthe thyroid, MOD PATHOL, 12(11), 1999, pp. 1057-1061
Citations number
31
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research Diagnosis & Treatment
Journal title
MODERN PATHOLOGY
ISSN journal
08933952 → ACNP
Volume
12
Issue
11
Year of publication
1999
Pages
1057 - 1061
Database
ISI
SICI code
0893-3952(199911)12:11<1057:ABMMIH>2.0.ZU;2-H
Abstract
We report here four additional cases of hyalinizing trabecular adenoma of t he thyroid and describe the findings of the accumulated basement membrane ( BM) material. Focal lumpy depositions of BM material were noted in the stro ma of all four tumors and were particularly prominent in two. Antibodies ag ainst type TV collagen and laminin strongly immunoreacted with this materia l, which also showed diastase-resistant periodic acid-Schiff positivity. Th e ultrastructural findings of accumulated basement membrane was examined in detail. The most striking ultrastructural findings were seen at the periph ery of the cell clusters, where the basal aspect of the tumor cells rested on a highly accumulated BM materials displaying mesh-like, fir-branching, o r frame-like appearances. Intracytoplasmic BM islands were frequently obser ved in neoplastic cells. These BM islands were membrane-bounded and focally continuous with the cell surface membrane, suggesting pseudointracytoplasm ic depositions of BM material due to marked cytoplasmic infoldings. From th e findings, electron microscopic features of accumulated BM material are ve ry characteristic in hyalinizing trabecular adenomas and can be discernible from other histologic types of BM-producing tumors.