Induction and regulation of the IgE response

Immunoglobulin E (IgE) is believed to be one of the major mediators of imme diate hypersensitivity reactions that underlie atopic conditions such as ur ticaria, seasonal allergy, asthma and anaphylaxis. Factors that control IgE production are therefore essential to the pathogenesis of these important afflictions. But a complete understanding of this topic is lacking, while n ew data have raised questions regarding the precise role of IgE in atopic d isease. Evolving concepts of IgE production and elimination are likely to c larify the importance of IgE in health and disease.