G. Fortin et al., Segmental specification of GABAergic inhibition during development of hindbrain neural networks, NAT NEUROSC, 2(10), 1999, pp. 873-877
A primordial rhythm-generating neural network emerges during the segmental
period of vertebrate hindbrain development, suggesting a common genetic bas
is to both the structure and network activity of the region. We show here t
hat segmentation influenced a postsegmental developmental step by which a G
ABAergic rhythm generator was incorporated into the primordial network and
increased rhythm frequency to near mature values. This process depended on
specifications in r3 and r5 that controlled, on the basis of a two-segment
repeat, later maturation of GABAergic inhibition.