Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome

Authors
Siarey, RJ Carlson, EJ Epstein, CJ Balbo, A Rapoport, SI Galdzicki, Z
Citation
Rj. Siarey et al., Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome, NEUROPHARM, 38(12), 1999, pp. 1917-1920
Citations number
12
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROPHARMACOLOGY
ISSN journal
00283908 → ACNP
Volume
38
Issue
12
Year of publication
1999
Pages
1917 - 1920
Database
ISI
SICI code
0028-3908(199912)38:12<1917:ISDITT>2.0.ZU;2-G
Abstract
Long-term potentiation (LTP) and depression (LTD) were investigated in hipp ocampus of a genetic model of Down syndrome, the segmental trisomy (Ts65Dn) mouse. Field excitatory postsynaptic potentials were recorded from hippoca mpal slices and LTP and LTD evoked sequentially. LTP decreased whereas LTD increased significantly in Ts65Dn compared with control hippocampus. (C) 19 99 Published by Elsevier Science Ltd. All rights reserved.