Synthesis and anti-HIV activity of catanionic analogs of galactosylceramide

Authors
Blanzat, M Perez, E Rico-Lattes, I Lattes, A
Citation
M. Blanzat et al., Synthesis and anti-HIV activity of catanionic analogs of galactosylceramide, NEW J CHEM, 23(11), 1999, pp. 1063-1065
Citations number
10
Categorie Soggetti
Chemistry
Journal title
NEW JOURNAL OF CHEMISTRY
ISSN journal
11440546 → ACNP
Volume
23
Issue
11
Year of publication
1999
Pages
1063 - 1065
Database
ISI
SICI code
1144-0546(199911)23:11<1063:SAAAOC>2.0.ZU;2-G
Abstract
Two-chain and gemini catanionic analogs of galactosylceramide were easily p repared in quantitative yields, affording high anti-HIV activities with low cytotoxicities on human cells (e.g. for gemini 4b an EC50 of 0.5 mu M with a CC50 of >100 mu M were obtained).