Palladium-catalyzed highly diastereoselective cyclic carbopalladation-carbonylative esterification tandem reaction of iododienes and iodoarylalkenes

[GRAPHICS] Pd-catalyzed reaction of iododienes and iodoarylalkenes represented by 1, 8 , and 10 under 1 atm of CO and a small amount of O-2 in the presence of a b ase, e.g., NEt3 as well as MeOH and H2O in DMF can undergo a highly diaster eoselective cyclic carbopalladation-carbonylative esterification tandem pro cess (Type II C-Pd process) to give in high yields the corresponding ester- containing cyclization products, e.g., 2, 9, and 11, in as high as 98% dias tereoselectivity.