Cellular toxicity of N-substituted 2,2 '-dicarboxamidodiphenyldisulphides with high antimicrobial activity

In the present paper we evaluate the cellular toxicity of some N-substitute d 2,2'-dicarboxamidodiphenyldisulphides with high antimicrobial activities, in view of their potential application in humans or animals. The toxicolog ical studies have been conducted in the murine cell line of 3T3 fibroblasts as eucaryotic cellular model. Our results have allowed the identification of a series of derivatives exhibiting antimicrobial activity and low cellul ar toxicity. Structure-cytotoxic activity relationships are also discussed. (C) 1999 Academic Press.