Using a modification of the ELISA method, auto-antibodies against the own n
ervous tissue have been identified in the serum of laboratory rats. The pre
valence of the IgM class of antibodies suggests their physiological signifi
cance. Antibody levels are higher in females than in males. Brain hypoxic i
njury brings about a shift in the spectrum of antibodies rewards the IgG cl
ass. It I nay thus serve as an indicator of brain impairment caused by a la
ck of oxygen.