A genetic dissection of the retinoid signalling pathway in the mouse

Authors
Mark, M Ghyselinck, NB Wendling, O Dupe, V Mascrez, B Kastner, P Chambon, P
Citation
M. Mark et al., A genetic dissection of the retinoid signalling pathway in the mouse, P NUTR SOC, 58(3), 1999, pp. 609-613
Citations number
33
Categorie Soggetti
Food Science/Nutrition","Endocrinology, Nutrition & Metabolism
Journal title
PROCEEDINGS OF THE NUTRITION SOCIETY
ISSN journal
00296651 → ACNP
Volume
58
Issue
3
Year of publication
1999
Pages
609 - 613
Database
ISI
SICI code
0029-6651(199908)58:3<609:AGDOTR>2.0.ZU;2-L
Abstract
To determine the functions of retinoic acid receptors RAR and RXR, we have systematically knocked-out their genes by homologous recombination in the e mbryonic stem cells and generated null-mutant mice. This approach has allow ed us to perform a genetic dissection of the retinoic acid signalling pathw ay.