This retrospective study included eight patients with villonodular syn
ovitis of the knee (7 nodular forms and one villous form) who underwen
t magnetic resonance imaging and at least one arthroscopy. Joint enlar
gement and mild pain were the main manifestations. Other imaging studi
es provided little information. Magnetic resonance imaging showed high
ly suggestive hemosiderin-laden masses. Hemosiderin was most clearly s
een on gradient echo sequences. Magnetic resonance imaging was also us
eful for determining the distribution of lesions. Intravenous gadolini
um provided no additional information. Arthroscopy allowed to collect
biopsy specimens and to perform synovectomy when called for. In our op
inion, after a physical examination and plain roentgenograms, magnetic
resonance imaging and arthroscopy should both be performed to determi
ne the extent of lesions and to allow histological diagnosis and synov
ectomy, respectively.