Polymorphisms within the interleukin-10 receptor cDNA gene (IL10R) in Japanese patients with systemic lupus erythematosus

Authors
Nakashima, H Akahoshi, M Tanaka, Y Yamaoka, K Ogami, E Nagano, S Arinobu, Y Niiro, H Otsuka, T Niho, Y
Citation
H. Nakashima et al., Polymorphisms within the interleukin-10 receptor cDNA gene (IL10R) in Japanese patients with systemic lupus erythematosus, RHEUMATOLOG, 38(11), 1999, pp. 1142-1144
Citations number
18
Categorie Soggetti
Rheumatology
Journal title
RHEUMATOLOGY
ISSN journal
14620324 → ACNP
Volume
38
Issue
11
Year of publication
1999
Pages
1142 - 1144
Database
ISI
SICI code
1462-0324(199911)38:11<1142:PWTIRC>2.0.ZU;2-L
Abstract
Objective. To assess the association between polymorphisms within the inter leukin-10 receptor cDNA gene (IL10R) and systemic erythematosus (SLE) in Ja panese people. Method. We examined the IL-10 receptor genotype of 109 SLE patients and 102 healthy subjects by the reverse transcription-polymerase chain reaction-re striction fragment length polymorphism (RT-PCR-RFLP) method. Results. There was no difference in the IL10R genotype frequencies of these two groups. Conclusion. The IL10R genotype does not determine susceptibility to SLE in Japanese people.